The reference site for Pentoxifylline

Pentoxifylline (INN, BAN, USAN) or oxpentifylline (AAN) is a xanthine derivative used as a drug to treat muscle pain in people with peripheral artery disease.

WHAT IS Pentoxifylline?

Pentoxifylline is used to treat intermittent claudication in people who have peripheral arterial disease (PAD).

This medication increases the amount of oxygen that reaches your tissues by increasing the flexibility of your red blood cells. When blood cells are more flexible, they can travel more easily through narrowed blood vessels to deliver oxygen to muscle, bone, skin, and nerve tissues.

Pentoxifylline should not be used in people who have recently had bleeding (hemorrhage) in the back lining of the eye (retina) or the brain. It also should not be used by people who cannot tolerate caffeine.

 

Brand Name(s): Pentoxil; Trental
CAS nº: 6493-05-6
(pen tox I fi leen)

 

Product Info

The sections below will provide you with more specific information and guidelines related to pentoxifylline and its correct use. Please read them carefully.

FDA Information

Pentoxifylline was approved by the Food and Drug Administration in 1984. A prescription is required for this medicine.

Please visit the official site of the FDA for further information.

Why is this medication prescribed?

Pentoxifylline is used to treat intermittent claudication in people who have peripheral arterial disease (PAD).

This medication works by increasing the amount of oxygen that reaches your tissues by increasing the flexibility of your red blood cells. When blood cells are more flexible, they can travel more easily through narrowed blood vessels to deliver oxygen to muscle, bone, skin, and nerve tissues.

Pentoxifylline should not be used in people who have recently had bleeding (hemorrhage) in the back lining of the eye (retina) or the brain. It also should not be used by people who cannot tolerate caffeine.

Other uses for this medicine

Pentoxifylline is also used for leg ulcers, strokes, high-altitude sickness, eye and ear disorders, sickle cell disease and to treat pain from diabetic neuropathy.

However, it is important that you talk to your doctor about the possible risks of using this drug for your particular condition.

Dosage and using this medicine

Pentoxifylline comes as an extended-release (long-acting) tablet to be taken orally. It is usually taken three times a day.

Follow the directions on the prescription label.

Do not break, crush, or chew the tablets. Swallow them whole. They are specially coated to protect your stomach.

You can take pentoxifylline with food or antacids if it upsets your stomach.

Take your doses at regular intervals. Do not take your medicine more often than directed.

Contact your pediatrician or health care professional regarding the use of this medicine in children. Special care may be needed.

Moreover, elderly patients over 65 years old need smaller doses to reduce possible side effects.

Do not stop taking this medication suddenly. It may take up to 8 weeks for you to see beneficial effects from pentoxifylline.

What special precautions should I follow?

BEFORE TAKING PENTOXIFYLLINE:

Please note that you cannot take pentoxifylline if you have recently hemorrhaged (bled) in the eye or brain, or if you have an allergy to caffeine, theophylline (Theo-Dur®, Theo-Bid®), or theobromine.

Tell your doctor if you have an ulcer disease (stomach or duodenal ulcer), have recently had any type of surgery (including dental), have recently had a bleeding disorder, or have any type of liver disease. You may not be able to take pentoxifylline, or you may require a lower dose or special monitoring during treatment if you have any of the conditions listed above.

Please inform your doctor if you are taking warfarin (Coumadin®). Pentoxifylline may increase the effects of anticoagulants such as warfarin, which may result in bleeding.

Theophylline (Theo-Dur®, Theo-Bid®, Theolair®, Theochron®, Elixophyllin®, Slo-Phyllin®, others), aminophylline (Phyllocontin®, Truphylline®), dyphylline (Lufyllin®, Dylix®, Dilor®, Neothylline®), and oxtriphylline (Choledyl®) may cause dangerous side effects if taken at the same time as pentoxifylline. Your dosage of these drugs may have to be reduced or blood levels closely monitored. Talk to your doctor if you are currently taking any of these medicines.

Drugs other than those listed here may also interact with pentoxifylline. Talk to your doctor and pharmacist before taking or using any other prescription or over-the-counter medicines.

Pentoxifylline is in the FDA pregnancy category C. This means that it is not known whether pentoxifylline will harm an unborn baby. Do not take this medication without first talking to your doctor if you are pregnant.

Moreover, pentoxifylline passes into breast milk and may affect a nursing infant. Do not take this medication without first talking to your doctor if you are breast-feeding a baby.

Additionally, tobacco may worsen your condition or decrease the beneficial effects of pentoxifylline by narrowing your blood vessels. Talk to your doctor or pharmacist if you use tobacco.

What should I do if I forget a dose?

If you miss a dose of this medication, take it as soon as you remember up to 3 hours later. If more than 3 hours have passed, skip the dose you missed and take only your next regularly scheduled dose.

Never take a double dose of this medication.

What side effects can this medication cause?

If you experience any of the following serious side effects, stop taking pentoxifylline and seek medical attention:

an allergic reaction (difficulty breathing, closing of your throat, swelling of your lips, tongue, or face, or hives)
chest pain or an irregular heartbeat
severe dizziness, headache, nosebleeds, or blurred vision
nausea or vomiting
swollen feet or ankles

Other, less serious side effects may be more likely to occur. Continue to take pentoxifylline and talk to your doctor if you experience:

insomnia
red eyes
nervousness

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What storage conditions are needed for this medicine?

Always keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Please remember to throw away any medication that is outdated or no longer needed. If it is necessary, talk to your pharmacist about the proper disposal of your medication.

In case of an emergency/overdose

In the case of a suspected overdose, call your local poison control center on 1-800-222-1222. However, if the victim has collapsed or is not breathing, please call the local emergency services immediately on 911.

Symptoms of overdose may include:

seizures
agitation
fever
loss of consciousness
a flushed face
drowsiness

Product Images

PICTURES OF PENTOXIFYLLINE PILLS

Below you will find images and specific information on the principal types of pentoxifylline that exist, including their respective brand name(s), strength, inscription codes, manufacturers and/or distributors.

The information below includes general information and guidelines for patients taking this medication and should never be used to substitute professional medical advice that can be provided by a qualified physician or family doctor.

Name: PENTOXIFYLLINE
Strength(s): 400 MG
Imprint: MYLAN | 357
Manufacturer: MYLAN

Name: PENTOXIFYLLINE
Strength(s): 400 MG
Imprint: PLIVA | 609
Manufacturer: PLIVA, INC.

Name: PENTOXIFYLLINE
Strength(s): 400 MG
Imprint: BVF | 0117
Manufacturer: TEVA USA

Name: PENTOXIL®
Strength(s): 400 MG
Imprint: U-S 027
Manufacturer: UPSHER-SMITH LABS.
Distributors: PUREPAC & MCKESSON PACKAGING

Name: TRENTAL®
Strength(s): 400 MG
Imprint: TRENTAL | HOECHST
Manufacturer: HOECHST ROUSSEL (SANOFI-AVENTIS)
Distributors: MERRELL PHARM. & PHYSICIANS TOTALCARE

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